莫非赛定 Morphothiadin
交易须知
morphothiadin产品活性：morphothiadin 是野生型和阿德福韦耐药 hbv 复制的有效抑制剂，其 ic50 值为 12 nm。
研究领域：anti-infection
作用靶点：hbv
in vitro: morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant hbv with an ic50 of 12 nm. morphothiadin (gls4) shows no toxicity up to 25 μm. the cytotoxic dose whereby 50% of cells die (cc50) for primary hepatocytes is 115 μm for morphothiadin (p<0.001). the cc90 is 190 μm for morphothiadin (p<0.01) in hepad38 cells. morphothiadin strongly inhibits virus accumulation in the supernatant of hepad38 cells at 25 nm to 100 nm (p<0.02). results show a concentration-dependent decrease of core protein in cells treated with morphothiadin.
in vivo: the area under the concentration-time curve from 0 to 24 h (auc0-24) of morphothiadin (gls4) is 556 h•ng/ml. after intravenous administration of 10 mg/kg morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. the bioavailability of morphothiadin is 25.5%. it is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of morphothiadin. there is generally an inverse relationship between morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (p7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment.
相关产品：drug repurposing compound library | anti-infection compound library | anti-virus compound library | clinical compound library | clinical compound library plus | drug repurposing compound library plus | bioactive compound library plus | bay 41-4109 | entecavir monohydrate | tenofovir disoproxil fumarate | adefovir dipivoxil | squalamine | ab-423 | merimepodib | jnj-632 | bicyclol | inarigivir | rig-1 modulator 1 | oxethazaine | telbivudine | rg7834 | clevudine | osalmid | helioxanthin derivative 5-4-2 | ba-53038b | helioxanthin 8-1 | hepatitis b virus core 128-140 | lagociclovir
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
农村再也不穷啦！土地流转帮农民脱贫致富，坐在家里等着收钱
阿香米线加盟费用和加盟流程
渝城老妈教你如何做好餐饮营销
整形制具
专业的arcgis原理及操作课程培训中心-推荐中科信软
莫非赛定 Morphothiadin
水里来火里去 水火锻造出的安信纽敦豆实木地热地板
佳县野生红枣批发，干枣零售，1斤袋装，2-4斤礼盒
大型冷藏车，豪沃前四后四
杜邦103HSL原料
芝麻e柜货源怎么样？
逆势上涨，为何车市越低迷日系车就越坚挺？
采购黄焖鸡酱料就找源源流香食品 山东黄焖鸡酱料
加盟开一家鱼当道烤鱼加盟店
济南市露骨料透水混凝土彩色透水地坪彩色透水铺装
多功能芒果干烘干机优质厂家
江西国道公路护栏板安装厂家讲讲喷塑是什么
云南半永久化妆学校哪家技术一流？
关菊水白木柄锻打高级柳刀 刺身刀 西餐料理厨用刀
加盟服装行业选择品牌难的问题怎么解决
morphothiadin产品活性：morphothiadin 是野生型和阿德福韦耐药 hbv 复制的有效抑制剂，其 ic50 值为 12 nm。
研究领域：anti-infection
作用靶点：hbv
in vitro: morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant hbv with an ic50 of 12 nm. morphothiadin (gls4) shows no toxicity up to 25 μm. the cytotoxic dose whereby 50% of cells die (cc50) for primary hepatocytes is 115 μm for morphothiadin (p<0.001). the cc90 is 190 μm for morphothiadin (p<0.01) in hepad38 cells. morphothiadin strongly inhibits virus accumulation in the supernatant of hepad38 cells at 25 nm to 100 nm (p<0.02). results show a concentration-dependent decrease of core protein in cells treated with morphothiadin.
in vivo: the area under the concentration-time curve from 0 to 24 h (auc0-24) of morphothiadin (gls4) is 556 h•ng/ml. after intravenous administration of 10 mg/kg morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. the bioavailability of morphothiadin is 25.5%. it is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of morphothiadin. there is generally an inverse relationship between morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (p7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment.
相关产品：drug repurposing compound library | anti-infection compound library | anti-virus compound library | clinical compound library | clinical compound library plus | drug repurposing compound library plus | bioactive compound library plus | bay 41-4109 | entecavir monohydrate | tenofovir disoproxil fumarate | adefovir dipivoxil | squalamine | ab-423 | merimepodib | jnj-632 | bicyclol | inarigivir | rig-1 modulator 1 | oxethazaine | telbivudine | rg7834 | clevudine | osalmid | helioxanthin derivative 5-4-2 | ba-53038b | helioxanthin 8-1 | hepatitis b virus core 128-140 | lagociclovir
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
农村再也不穷啦！土地流转帮农民脱贫致富，坐在家里等着收钱
阿香米线加盟费用和加盟流程
渝城老妈教你如何做好餐饮营销
整形制具
专业的arcgis原理及操作课程培训中心-推荐中科信软
莫非赛定 Morphothiadin
水里来火里去 水火锻造出的安信纽敦豆实木地热地板
佳县野生红枣批发，干枣零售，1斤袋装，2-4斤礼盒
大型冷藏车，豪沃前四后四
杜邦103HSL原料
芝麻e柜货源怎么样？
逆势上涨，为何车市越低迷日系车就越坚挺？
采购黄焖鸡酱料就找源源流香食品 山东黄焖鸡酱料
加盟开一家鱼当道烤鱼加盟店
济南市露骨料透水混凝土彩色透水地坪彩色透水铺装
多功能芒果干烘干机优质厂家
江西国道公路护栏板安装厂家讲讲喷塑是什么
云南半永久化妆学校哪家技术一流？
关菊水白木柄锻打高级柳刀 刺身刀 西餐料理厨用刀
加盟服装行业选择品牌难的问题怎么解决