鲁索利替尼;卢索替尼;芦可替尼 Ruxolitinib
交易须知
ruxolitinib产品活性：ruxolitinib 是有效，选择性的 jak1/2 抑制剂， ic50 值分别为 3.3 nm和2.8 nm，选择性是 jak3 的 130 多倍。
研究领域：epigenetics | stem cell/wnt | jak/stat signaling | autophagy
作用靶点：jak | autophagy | mitophagy
in vitro: ruxolitinib potently and selectively inhibits jak2v617f-mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nm results in a doubling of cells with depolarized mitochondria in ba/f3 cells. ruxolitinib demonstrates remarkable potency against erythroid colony formation with ic50 of 67 nm, and inhibits proliferating of erythroid progenitors from normal donors and polycythemia vera patients with ic50 values of 407 nm and 223 nm, respectively.
in vivo: ruxolitinib (180 mg/kg, orally, twice a day) results in survive rate of greater than 90% by day 22 and markedly reduces splenomegaly and circulating levels of inflammatory cytokines, and preferentially eliminated neoplastic cells, resulting in significantly prolonged survival without myelosuppressive or immunosuppressive effects in a jak2v617f-driven mouse model. in the ruxolitinib group, the primary end point is reached in 41.9% of patients, as compared with 0.7% in the placebo group in the double-blind trial of myelofibrosis. ruxolitinib results in maintaining of reduction in spleen volume and improvement of 50% or more in the total symptom score. ruxolitinib (15 mg twice daily) treatment leads a total of 28% of the patients to have at least a 35% reduction in spleen volume at week 48 in patients with myelofibrosis, as compared with 0% in the group receiving the best available therapy. the mean palpable spleen length has decreased by 56% with ruxolitinib but has increased by 4% with the best available therapy at week 48. patients in the ruxolitinib group has an improvement in overall quality-of-life measures and a reduction in symptoms associated with myelofibrosis.
相关产品：fda-approved drug library plus | drug repurposing compound library | fda-approved drug library mini | anti-aging compound library | kinase inhibitor library | jak/stat compound library | stem cell signaling compound library | fda-approved drug library | anti-cancer compound library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | autophagy compound library | 3-methyladenine | olaparib | doxorubicin hydrochloride | sb 203580 | u0126 | metformin hydrochloride | aicar | brefeldin a | dexamethasone | etoposide | vorinostat | deferoxamine mesylate | tanespimycin | resveratrol | curcumin | melatonin | sunitinib | ruxolitinib phosphate | abt-737 | simvastatin | baricitinib | quercetin | salinomycin | valproic acid | tofacitinib | upadacitinib | hemin | tripterin | aspirin
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
集成墙板安装步骤和验收
输水管道专用TPEP防腐钢管
供应不锈钢箱变 箱式变电站
河南广东图像型火灾探测器如何维护保养
焖掌柜焖锅成本可控 开店更放心
鲁索利替尼;卢索替尼;芦可替尼 Ruxolitinib
小金井特价销售4V气控阀
志盛威华ZS-1071耐高温无机粘合剂，高温胶
西海岸专业企业内训，专业团队建设年轻没有失败，只要亮出风采
饱和蒸汽流量计哪家好 高温型蒸汽流量计 高压蒸汽流量计选型
吴江系统阳光房厂家诺康值得信赖
江苏天琦岩棉平板生产厂家简述关于环境保护的问题
怀化不锈钢移动铁马厂家直销价格优惠
世程地暖管路清洗 延长地暖管使用寿命
厂家直销红木花梨木双人床1.8米国色天香大床中式古典红木床
定边围挡板价格 宁夏龙士达
工厂厂服工衣|制服厂家工作服POLO衫|新圩汽修电焊帆布工衣
鸡场的鸡粪水分太大如何做成有机肥？
ps优质低价材料|ps扩散板材料|武隆奉节ps扩散板
浩泽直饮机加盟有哪些要求？加盟浩泽直饮机做稳定实业
ruxolitinib产品活性：ruxolitinib 是有效，选择性的 jak1/2 抑制剂， ic50 值分别为 3.3 nm和2.8 nm，选择性是 jak3 的 130 多倍。
研究领域：epigenetics | stem cell/wnt | jak/stat signaling | autophagy
作用靶点：jak | autophagy | mitophagy
in vitro: ruxolitinib potently and selectively inhibits jak2v617f-mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nm results in a doubling of cells with depolarized mitochondria in ba/f3 cells. ruxolitinib demonstrates remarkable potency against erythroid colony formation with ic50 of 67 nm, and inhibits proliferating of erythroid progenitors from normal donors and polycythemia vera patients with ic50 values of 407 nm and 223 nm, respectively.
in vivo: ruxolitinib (180 mg/kg, orally, twice a day) results in survive rate of greater than 90% by day 22 and markedly reduces splenomegaly and circulating levels of inflammatory cytokines, and preferentially eliminated neoplastic cells, resulting in significantly prolonged survival without myelosuppressive or immunosuppressive effects in a jak2v617f-driven mouse model. in the ruxolitinib group, the primary end point is reached in 41.9% of patients, as compared with 0.7% in the placebo group in the double-blind trial of myelofibrosis. ruxolitinib results in maintaining of reduction in spleen volume and improvement of 50% or more in the total symptom score. ruxolitinib (15 mg twice daily) treatment leads a total of 28% of the patients to have at least a 35% reduction in spleen volume at week 48 in patients with myelofibrosis, as compared with 0% in the group receiving the best available therapy. the mean palpable spleen length has decreased by 56% with ruxolitinib but has increased by 4% with the best available therapy at week 48. patients in the ruxolitinib group has an improvement in overall quality-of-life measures and a reduction in symptoms associated with myelofibrosis.
相关产品：fda-approved drug library plus | drug repurposing compound library | fda-approved drug library mini | anti-aging compound library | kinase inhibitor library | jak/stat compound library | stem cell signaling compound library | fda-approved drug library | anti-cancer compound library | drug repurposing compound library plus | epigenetics compound library | bioactive compound library plus | autophagy compound library | 3-methyladenine | olaparib | doxorubicin hydrochloride | sb 203580 | u0126 | metformin hydrochloride | aicar | brefeldin a | dexamethasone | etoposide | vorinostat | deferoxamine mesylate | tanespimycin | resveratrol | curcumin | melatonin | sunitinib | ruxolitinib phosphate | abt-737 | simvastatin | baricitinib | quercetin | salinomycin | valproic acid | tofacitinib | upadacitinib | hemin | tripterin | aspirin
MedChemExpress LLC
郑先生
86-021-58955995
17321200539
集成墙板安装步骤和验收
输水管道专用TPEP防腐钢管
供应不锈钢箱变 箱式变电站
河南广东图像型火灾探测器如何维护保养
焖掌柜焖锅成本可控 开店更放心
鲁索利替尼;卢索替尼;芦可替尼 Ruxolitinib
小金井特价销售4V气控阀
志盛威华ZS-1071耐高温无机粘合剂，高温胶
西海岸专业企业内训，专业团队建设年轻没有失败，只要亮出风采
饱和蒸汽流量计哪家好 高温型蒸汽流量计 高压蒸汽流量计选型
吴江系统阳光房厂家诺康值得信赖
江苏天琦岩棉平板生产厂家简述关于环境保护的问题
怀化不锈钢移动铁马厂家直销价格优惠
世程地暖管路清洗 延长地暖管使用寿命
厂家直销红木花梨木双人床1.8米国色天香大床中式古典红木床
定边围挡板价格 宁夏龙士达
工厂厂服工衣|制服厂家工作服POLO衫|新圩汽修电焊帆布工衣
鸡场的鸡粪水分太大如何做成有机肥？
ps优质低价材料|ps扩散板材料|武隆奉节ps扩散板
浩泽直饮机加盟有哪些要求？加盟浩泽直饮机做稳定实业