Estrogen Receptor alpha文献引用
英文名称 estrogen receptor alpha
中文名称 雌激素受体α抗体
别 名 estradiol receptor; estrogen receptor alpha; estradiol receptor-alpha; estrogen receptor 1; atherosclerosis, susceptibility to, included; dkfzp686n23123; er alpha; er; er-alpha; eralpha; er[a]; era; esr; esr1; esr1_human; esr2; esra; estr; estrogen receptor 1 (alpha); estrogen resistance, included; hdl cholesterol, augmented response of, to hormone replacement, included; myocardial infarction, susceptibility to, included; nr3a1; nuclear receptor subfamily 3 group a member 1; otthump00000017718; otthump00000017719; rnestror.
specific references (1) | bs-0122r has been referenced in 1 publications.
[if=1.85] zhou, dawei, et al. estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17?\estradiol and insulin?\like growth factor 1.ll biochemistry and function 29.2 (2011): 120-125.... wb ; mouse.
pubmed:21287577
规格价格 50ul/780元 100ul/1380元 200ul/2200元 大包装/询价
说 明 书 50ul 100ul 200ul
研究领域 肿瘤 免疫学 生长因子和激素
抗体来源 rabbit
克隆类型 polyclonal
交叉反应 human, mouse, rat, dog, cow, rabbit,
产品应用 wb=1:500-2000 elisa=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kda
细胞定位 细胞核
性 状 lyophilized or liquid
浓 度 1mg/ml
免 疫 原 klh conjugated synthetic peptide derived from the middle of human estrogen receptor alpha:331-360/595
亚 型 igg
纯化方法 affinity purified by protein a
储 存 液 0.01m tbs(ph7.4) with 1% bsa, 0.03% proclin300 and 50% glycerol.
保存条件 store at -20 °c for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°c. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4 °c.
pubmed pubmed
产品介绍 background:
estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. the interaction of hormone-bound estrogen receptors with estrogen responsive elements(eres) alters transcription of ere-containing genes. the carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the dna binding domain is centrally located. two forms of estrogen receptor have been identified, er alpha and er beta. er alpha and er beta have been shown to be differentially activated by various ligands. the biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hpr-a and hpr-b), which arise from alternative splicing. in most cells, hpr-b functions as a transcriptional activator of progesterone-responsive gene, whereas hpr-a function as a transcriptional inhibitor of all steroid hormone receptors.
function:
nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
subunit:
interacts with slc30a9 (by similarity). binds dna as a homodimer. can form a heterodimer with esr2. interacts with ncoa3, ncoa5 and ncoa6 coactivators, leading to a strong increase of transcription of target genes. interacts with ncoa7 in a ligand-inducible manner. interacts with phb2, pelp1 and ube1c. interacts with akap13. interacts with cuedc2. interacts with kdm5a. interacts with smard1. interacts with hexim1 and map1s. interacts with pbxip1. interaction with muc1 is stimulated by 7 beta-estradiol (e2) and enhances ers1-mediated transcription. interacts with dnttip2, fam120b and uimc1. interacts with isoform 4 of txnrd1. interacts with mll2. interacts with atad2 and this interaction is enhanced by estradiol.
subcellular location:
nucleus.
post-translational modifications:
phosphorylated by cyclin a/cdk2. phosphorylation probably enhances transcriptional activity.
glycosylated; contains n-acetylglucosamine, probably o-linked.
similarity:
belongs to the nuclear hormone receptor family. nr3 subfamily.
contains 1 nuclear receptor dna-binding domain.
swiss:
p06211
gene id:
2099
database links:entrez gene: 407238 cow
entrez gene: 403640 dog
entrez gene: 2099 human
entrez gene: 13982 mouse
entrez gene: 24890 rat
omim: 133430 human
swissprot: p49884 cow
swissprot: p03372 human
important note:
this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
类固醇受体（steroid receptors）
雌激素受体er-α（estrogen receptor-α, erα）是一类位于细胞表面或细胞内的特异性蛋白质。
某些特异的雌激素、雌激素类似物、衍生物、拮抗剂或阻断剂与它结合后可引发或阻断受体蛋白质的转化作用。并将雌激素-受体复合物从细胞质再定位进入细胞核以启动蛋白质的生物合成。
产品图片
sample:mcf-7 cell lysate at 30ug;
primary: anti-estrogen receptor alpha (bs-0122r) at 1:300;
secondary: hrp conjugated goat-anti-rabbit igg(bs-0295g-hrp) at 1: 5000;
predicted band size: 67 kd
observed band size: 67 kd
sample:
mcf-7 cell lysate at 30ug;
du145 cell lysate at 30 ug;
primary: anti-estrogen receptor alpha (bs-0122r) at 1:300;
secondary: hrp conjugated goat-anti-rabbit igg(bs-0295g-hrp) at 1: 5000;
predicted band size: 67 kd
observed band size: 67 kd
sample:
a549(human) cell lysate at 30 ug
primary: anti-estrogen receptor alpha (bs-0122r) at 1/300 dilution
secondary: irdye800cw goat anti-rabbit igg at 1/20000 dilution
predicted band size: 67 kd
observed band size: 67 kd
sample: mcf-7 cell (human) lysate at 30 ug
primary: anti- estrogen receptor alpha (bs-0122r)at 1/300 dilution
secondary: irdye800cw goat anti-rabbit igg at 1/20000 dilution
predicted band size: 67kd
observed band size: 65kd
上海雅吉生物科技有限公司
大型厂家指定供应商[跨越电子]定制灯具专用导热硅胶片
东莞石排镇到和龙货运专线 方便快捷_靠谱的物流公司
PALL-VacuCap盖式真空过滤器
海澜花 H-1504电动晾衣架 2.6米四杆升降遥控款
YD988耐磨堆焊焊丝YD988高硬度耐磨堆焊焊丝
Estrogen Receptor alpha文献引用
供应木材宝兰SF-B
释放器批发
福瑞斯总部（站）
江宁区找代理记账丨小规模代理记账
汽车线磷化除渣机品牌 箭神厂家几十年的老品牌更可靠
整柜进口聚氨酯树脂、石油树脂 树脂进口流程
品牌移动电源 捷巢 LED照明 超长续航
纸包鱼加盟多少钱 一纸馋轻投资小档口即可开店
商标的注册流程及费用 商标国外注册费用
“秋名山神车”也出PLUS版啦！换装1.5T还有7/8座选择
GCRAE 便携式气相色谱仪 PGA-1020
不要再担心孩子的学习了！青鸟园丁解决各种学习的苦恼！
混凝土搅拌机价格 混凝土搅拌站多少钱一台
投资加盟茶知否纯手工茶饮 总部一站式扶持让你安心创业
中文名称 雌激素受体α抗体
别 名 estradiol receptor; estrogen receptor alpha; estradiol receptor-alpha; estrogen receptor 1; atherosclerosis, susceptibility to, included; dkfzp686n23123; er alpha; er; er-alpha; eralpha; er[a]; era; esr; esr1; esr1_human; esr2; esra; estr; estrogen receptor 1 (alpha); estrogen resistance, included; hdl cholesterol, augmented response of, to hormone replacement, included; myocardial infarction, susceptibility to, included; nr3a1; nuclear receptor subfamily 3 group a member 1; otthump00000017718; otthump00000017719; rnestror.
specific references (1) | bs-0122r has been referenced in 1 publications.
[if=1.85] zhou, dawei, et al. estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17?\estradiol and insulin?\like growth factor 1.ll biochemistry and function 29.2 (2011): 120-125.... wb ; mouse.
pubmed:21287577
规格价格 50ul/780元 100ul/1380元 200ul/2200元 大包装/询价
说 明 书 50ul 100ul 200ul
研究领域 肿瘤 免疫学 生长因子和激素
抗体来源 rabbit
克隆类型 polyclonal
交叉反应 human, mouse, rat, dog, cow, rabbit,
产品应用 wb=1:500-2000 elisa=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kda
细胞定位 细胞核
性 状 lyophilized or liquid
浓 度 1mg/ml
免 疫 原 klh conjugated synthetic peptide derived from the middle of human estrogen receptor alpha:331-360/595
亚 型 igg
纯化方法 affinity purified by protein a
储 存 液 0.01m tbs(ph7.4) with 1% bsa, 0.03% proclin300 and 50% glycerol.
保存条件 store at -20 °c for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°c. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4 °c.
pubmed pubmed
产品介绍 background:
estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. the interaction of hormone-bound estrogen receptors with estrogen responsive elements(eres) alters transcription of ere-containing genes. the carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the dna binding domain is centrally located. two forms of estrogen receptor have been identified, er alpha and er beta. er alpha and er beta have been shown to be differentially activated by various ligands. the biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hpr-a and hpr-b), which arise from alternative splicing. in most cells, hpr-b functions as a transcriptional activator of progesterone-responsive gene, whereas hpr-a function as a transcriptional inhibitor of all steroid hormone receptors.
function:
nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
subunit:
interacts with slc30a9 (by similarity). binds dna as a homodimer. can form a heterodimer with esr2. interacts with ncoa3, ncoa5 and ncoa6 coactivators, leading to a strong increase of transcription of target genes. interacts with ncoa7 in a ligand-inducible manner. interacts with phb2, pelp1 and ube1c. interacts with akap13. interacts with cuedc2. interacts with kdm5a. interacts with smard1. interacts with hexim1 and map1s. interacts with pbxip1. interaction with muc1 is stimulated by 7 beta-estradiol (e2) and enhances ers1-mediated transcription. interacts with dnttip2, fam120b and uimc1. interacts with isoform 4 of txnrd1. interacts with mll2. interacts with atad2 and this interaction is enhanced by estradiol.
subcellular location:
nucleus.
post-translational modifications:
phosphorylated by cyclin a/cdk2. phosphorylation probably enhances transcriptional activity.
glycosylated; contains n-acetylglucosamine, probably o-linked.
similarity:
belongs to the nuclear hormone receptor family. nr3 subfamily.
contains 1 nuclear receptor dna-binding domain.
swiss:
p06211
gene id:
2099
database links:entrez gene: 407238 cow
entrez gene: 403640 dog
entrez gene: 2099 human
entrez gene: 13982 mouse
entrez gene: 24890 rat
omim: 133430 human
swissprot: p49884 cow
swissprot: p03372 human
important note:
this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
类固醇受体（steroid receptors）
雌激素受体er-α（estrogen receptor-α, erα）是一类位于细胞表面或细胞内的特异性蛋白质。
某些特异的雌激素、雌激素类似物、衍生物、拮抗剂或阻断剂与它结合后可引发或阻断受体蛋白质的转化作用。并将雌激素-受体复合物从细胞质再定位进入细胞核以启动蛋白质的生物合成。
产品图片
sample:mcf-7 cell lysate at 30ug;
primary: anti-estrogen receptor alpha (bs-0122r) at 1:300;
secondary: hrp conjugated goat-anti-rabbit igg(bs-0295g-hrp) at 1: 5000;
predicted band size: 67 kd
observed band size: 67 kd
sample:
mcf-7 cell lysate at 30ug;
du145 cell lysate at 30 ug;
primary: anti-estrogen receptor alpha (bs-0122r) at 1:300;
secondary: hrp conjugated goat-anti-rabbit igg(bs-0295g-hrp) at 1: 5000;
predicted band size: 67 kd
observed band size: 67 kd
sample:
a549(human) cell lysate at 30 ug
primary: anti-estrogen receptor alpha (bs-0122r) at 1/300 dilution
secondary: irdye800cw goat anti-rabbit igg at 1/20000 dilution
predicted band size: 67 kd
observed band size: 67 kd
sample: mcf-7 cell (human) lysate at 30 ug
primary: anti- estrogen receptor alpha (bs-0122r)at 1/300 dilution
secondary: irdye800cw goat anti-rabbit igg at 1/20000 dilution
predicted band size: 67kd
observed band size: 65kd
上海雅吉生物科技有限公司
大型厂家指定供应商[跨越电子]定制灯具专用导热硅胶片
东莞石排镇到和龙货运专线 方便快捷_靠谱的物流公司
PALL-VacuCap盖式真空过滤器
海澜花 H-1504电动晾衣架 2.6米四杆升降遥控款
YD988耐磨堆焊焊丝YD988高硬度耐磨堆焊焊丝
Estrogen Receptor alpha文献引用
供应木材宝兰SF-B
释放器批发
福瑞斯总部（站）
江宁区找代理记账丨小规模代理记账
汽车线磷化除渣机品牌 箭神厂家几十年的老品牌更可靠
整柜进口聚氨酯树脂、石油树脂 树脂进口流程
品牌移动电源 捷巢 LED照明 超长续航
纸包鱼加盟多少钱 一纸馋轻投资小档口即可开店
商标的注册流程及费用 商标国外注册费用
“秋名山神车”也出PLUS版啦！换装1.5T还有7/8座选择
GCRAE 便携式气相色谱仪 PGA-1020
不要再担心孩子的学习了！青鸟园丁解决各种学习的苦恼！
混凝土搅拌机价格 混凝土搅拌站多少钱一台
投资加盟茶知否纯手工茶饮 总部一站式扶持让你安心创业